Our patented technology enables a multiplex and high-throughput assay of histone post-translational modifications. At its core, the workflow utilises chromatin immunoprecipitation sequencing (ChIP-seq) and library preparation, requiring minimal adjustments for ChIP-seq useres to adopt in their laboratories. Multiplexing (multiple targets) and high-throughput (multiple samples) is combined to streamline large-scale ChIP-seq experiments, reduce unspecific background and enable direct quantitative comparisons between samples. The proprietary design is also compatible with mapping transcription factors and other chromatin-associated proteins, providing a robust workflow from sample to quantitative data for numerous fields of interest. With minor adjustments, target panels can be adopted to include DNA methylation, and other epigenetic markers.
Our kits generate up to 9 sequencing-ready Illumina libraries. We offer a dedicated quantitative data analysis pipeline that simplifies the user experience and enables full utilisation of the multiplexed data. The pipeline is built on open-source technology, allowing bioinformaticians to fully customise the software according to their specific needs.
Mouse embryonic stem cells, 8 conditions (additional replicates not shown), 2 histone post-translational modifications, 2 chromatin proteins: